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When your pet receives isoxazoline flea or tick medications, those compounds work in insects by disabling their GABA-gated chloride channels and simultaneously over-stimulating excitatory pathways, leading to fatal nervous-system overstimulation of the parasitexxiii
10.1016/j.ejphar.2019.172593 137 TabataY.NaganoA.IkadaY
A 2026 review published in Andrology consolidated the mechanistic evidence: kisspeptin modulation of GnRH pulsatility represents a testable biomarker pathway for differentiating PMOS from functional hypothalamic amenorrhea, and potentially for targeted therapeutic intervention
Products for human use might contain excipients that are fine for people but harmful to dogs
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